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Hence, the metabolite is liable for about 20% of sildenafil's motion. Sildenafil is excreted as metabolites predominantly inside the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around thirteen% of your administered oral dose). If taken that has a substantial-Excess fat meal, absorption is reduced; some time taken to succeed in the utmost plasma concentration increases by all-around just one hour, and the utmost concentration alone is lowered by almost one-3rd.[52]
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